โ Scribed by Chen, K.K. ;Hargreaves, Chester C. ;Winchester, William T.
No coin nor oath required. For personal study only.
In 1875 Gallois and Hardy (l), (2) first succeeded in isolating the alkaloid erythrophleine from the African sassy bark (Erythrophleum guineense, family leguminosere). For fully sixty years erythrophleine remained the only alkaloid known to have a digitalis-like action upon the heart, although scientific investigations were made repeatedly by Harnack and Zabrocki (3), Harnack (4), Kralsheimer (5), Power and Salway (6) and Maplethorpe (7). Other species of Erythrophleum were also studied such as E. coumingu by Gallois and Hardy (2). E. Zuboucherii by Petrie (8), and E. lasianthum by Kamerman (Q), but no new alkaloid was reported. Brill and Wells (10) stated that the bark of E . densiflorum of the Philippine Islands yielded no alkaloidal constituents. I t was not until 1935 that Dalma (11) separated four other alkaloids from the bark of E . guineense:
nor-cassaidine, C Z ~H ~O ~, and homophleine CasHasOpN2. The first three are crystalline while the last one is amorphous. Their toxicity and general action in frogs, rats and rabbits have been tested by Santi and Zweifel (12). Dalma (13)
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