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The Post-Polyketide Synthase Modification Steps in the Biosynthesis of the Antitumor Agent Ansamitocin by Actinosynnema p retiosum

✍ Scribed by Spiteller, Peter; Bai, Linquan; Shang, Guangdong; Carroll, Brian J.; Yu, Tin-Wein; Floss, Heinz G.

Book ID
127290118
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
50 KB
Volume
125
Category
Article
ISSN
0002-7863

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## Abstract The biosynthesis of the antitumor antibiotic, ansamitocin, involves the assembly of a linear octaketide on the ansamitocin (__asm__) polyketide synthase (PKS), which is then cyclized to proansamitocin and further modified to the final product. In the first chain‐extension step on the __