✦ LIBER ✦

The possible role of the fibroblast in granuloma-induced bone resorption in the rat

✍ Scribed by Dr. D. A. Deporter

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 872 KB
Volume: 127
Category: Article
ISSN: 0022-3417
DOI: 10.1002/path.1711270203

No coin nor oath required. For personal study only.

✦ Synopsis

Granulomas were produced over the calvaria of rats by injection of a mixture of turpentine and peanut oil. The granulomas induced localised areas of bone resorption and these resorptive lesions were examined at the fine structural level. A close association was found between osteoclasts and fibroblasts at resorbing surfaces. Furthermore, fibroblasts but not osteoclasts were observed to engulf and phagocytose bone collagen fibrils. It is suggested that the fibroblast either alone or in collaboration with the osteoclast is involved in the destruction of bone collagen during chronic inflammatory disorder of bone.

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