𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The possibilities of predicting allergic effects of new antirheumatics

✍ Scribed by J. Grimová; J. Lašťovička; H. Frycová; J. Krejčí

Book ID
105474958
Publisher
SP Birkhäuser Verlag Basel
Year
1988
Tongue
English
Weight
168 KB
Volume
23
Category
Article
ISSN
1420-908X

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Possible factor for nonlinear pharmacoki
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✍ Yoshihiko Tagawa; Kiyoshi Miwa; Kenji Yamashita; Ryoichi Tsukuda; Yoshinobu Yosh 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 158 KB

A new antirheumatic, TAK-603, shows nonlinear pharmacokinetics in both animals and humans. To elucidate the mechanism of these nonlinear pharmacokinetics, in vivo and in vitro metabolism of 14 C-labeled TAK-603 ([ 14 C]TAK-603) was studied using rats as these resemble humans in their metabolic profi