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The positive charge at Lys-288 of the glucagon-like peptide-1 (GLP-1) receptor is important for binding the N-terminus of peptide agonists

โœ Scribed by Suleiman Al-Sabah; Dan Donnelly


Book ID
117105844
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
184 KB
Volume
553
Category
Article
ISSN
0014-5793

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Charge inversion at position 68 of the g
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## Abstract Glucagon and glucagonโ€like peptideโ€1 (GLPโ€1)are two structurally related hormones that acutely regulate glucose control in opposite directions through homologous receptors. The molecular basis for selectivity between these two hormones and their receptors is of physiological and medicin