The position of the M-BCR breakpoint does not predict the duration of chronic phase or survival in chronic myeloid leukaemia
โ Scribed by Jerome Jaubert; Philippe Martiat; Charles Dowding; Norbert Ifrah; John M. Goldman
- Book ID
- 114711985
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 552 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0007-1048
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We report the sublocalization of the breakpoint in chromosome 22 in 33 patients with chronic myeloid leukemia (CML) who also had unusual marrow cytogenetics. In 23 patients, the leukemic clones were characterized by Philadelphia (Ph') chromosomes that arose through complex translocations that involv
## Abstract We have sought to define the relationship between the proportion of marrow metaphases showing the Philadelphia chromosome (Ph) and levels of __BCRโABL__ mRNA assessed by quantitative polymerase chain reaction (PCR) in patients with chronic myeloid leukaemia (CML). From a total of 141 pa