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The Polysialic Acid Moiety of the Neural Cell Adhesion Molecule Is Involved in Intraretinal Guidance of Retinal Ganglion Cell Axons

✍ Scribed by Philippe P. Monnier; Sven G.M. Beck; Jürgen Bolz; Sigrid Henke-Fahle

Book ID
115598633
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
400 KB
Volume
229
Category
Article
ISSN
0012-1606

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The a-2,Slinked polysialic acid (PSA) modification of the neural cell adhesion molecule (NCAM) modulates morphogenetic cell interactions. PSA is strongly expressed during neural development and generally down-regulated in the adult. However, it remains prominent in some areas of the brain, e.g., the