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The polymorphisms of 5, 10-methylenethtrahydrofolate reductase (MTHFR C677T and A1298C) and methionine synthase reductase (MTRR A66G) gene as maternal risk factors for fetal aneuploidy

✍ Scribed by Hyun-Mee Ryu; Do-Jin Kim; Moon-Young Kim; So-Yeon Park; Jin-Woo Kim; Shin-Young Kim; Jae-Hyug Yang; Joung-Yeol Han; Joo Oh Kim; Jin-Hoon Chung


Book ID
113428328
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
67 KB
Volume
191
Category
Article
ISSN
1097-6868

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Evaluation of C677T and A1298C polymorph
✍ Ana Paula Carneiro Brandalize; Eliane Bandinelli; Pollyanna Almeida dos Santos; πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 119 KB πŸ‘ 1 views

## Abstract Abnormal folate/homocysteine metabolism due to polymorphisms in genes involved in this pathway has been implicated as an etiologic factor in Down syndrome (DS). This case–control study aimed to evaluate the effect of maternal C677T and A1298C polymorphisms of the methylenetetrahydrofola