✦ LIBER ✦
The polyketide folding mode in the biogenesis of isoshinanolone and plumbagin from Ancistrocladus heyneanus (Ancistrocladaceae)
✍ Scribed by Gerhard Bringmann; Michael Wohlfarth; Heiko Rischer; Markus Rückert; Jan Schlauer
- Book ID
- 104260150
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 234 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The biosynthetic origins of the tetralone isoshinanolone and the related naphthoquinone phimbagin were investigated by feeding [13C2]-acetate to suspended callus cultures of Ancistrocladus heyneanus. The orientation of the acetate subunits was elucidated by a similax experiment using [2-~3C]-acetate. The polyketide folding mode found for isoshinanolonc and plumbagin constitutes a further hint at the acetogenic nature of the naphthylisoquinoline alkaloids, which are typical of A.
heyneanus and other species of Ancistrocladaceac and Dioacophyllaceae.