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The PNPLA3 I148M polymorphism is associated with insulin resistance and nonalcoholic fatty liver disease in a normoglycaemic population

✍ Scribed by Chih-Wen Wang; Hsing-Yi Lin; Shyi-Jang Shin; Ming-Lung Yu; Zu-Yau Lin; Chia-Yen Dai; Jee-Fu Huang; Shinn-Cherng Chen; Steven Shoei-Lung Li; Wan-Long Chuang

Book ID: 111239537
Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 147 KB
Volume: 31
Category: Article
ISSN: 0106-9543
DOI: 10.1111/j.1478-3231.2011.02526.x

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Inherited factors play a major role in the predisposition to nonalcoholic fatty liver disease (NAFLD), and the rs738409 CfiG polymorphism of PNPLA3/adiponutrin, encoding for the isoleucine-to-methionine substitution at residue 148 (I148M) protein variant, has recently been recognized as a major dete