✦ LIBER ✦

The pivotal role of hepatocytes in drug discovery

✍ Scribed by Matthew G. Soars; Dermot F. McGinnity; Ken Grime; Robert J. Riley

Book ID: 113517462
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 486 KB
Volume: 168
Category: Article
ISSN: 0009-2797
DOI: 10.1016/j.cbi.2006.11.002

No coin nor oath required. For personal study only.

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## Abstract Metabolism by the host organism is one of the most important determinants of the pharmacokinetic profile of a drug. High metabolic lability usually leads to poor bioavailability and high clearance. Formation of active or toxic metabolites will have an impact on the pharmacological and t