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The Pinene Path to Taxanes. 5. Stereocontrolled Synthesis of a Versatile Taxane Precursor

✍ Scribed by Wender, Paul A.; Badham, Neil F.; Conway, Simon P.; Floreancig, Paul E.; Glass, Timothy E.; Gränicher, Christian; Houze, Jonathan B.; Jänichen, Jan; Lee, Daesung; Marquess, Daniel G.; McGrane, Paul L.; Meng, Wei; Mucciaro, Thomas P.; Mühlebach, Michel; Natchus, Michael G.; Paulsen, Holger; Rawlins, David B.; Satkofsky, Jeffrey; Shuker, Anthony J.; Sutton, James C.; Taylor, Richard E.; Tomooka, Katsuhiko


Book ID
121412758
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
142 KB
Volume
119
Category
Article
ISSN
0002-7863

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A synthetic approach to taxane diterpene
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Bicyclo[5.3.l]undecenone 2 corresponding to A and B rings in taxane diterpenes was synthesized. The eight-membered ring was constructed by a baseinduced intramolecular cyclization of twelve-membered lactam sulfoxides 15. 204 lja,b ya,bl,b2 isomer NC-S J K \*H,6 5 4 9 07 / 11' 1 3 10 -. 2 0 H R NHMe