The photobiology of melanocytes modulates the impact of UVA on sunlight-induced melanoma
✍ Scribed by Mitchell, David ;Fernandez, André
- Book ID
- 118121961
- Publisher
- Royal Society of Chemistry
- Year
- 2012
- Tongue
- English
- Weight
- 148 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1474-905X
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Normal human epidermal melanocytes are attached to a basement membrane, a specialized form of extracellular matrix (ECM), located between the epithelium and underlying dermal tissues. To determine whether ECM influences pigmented cell behavior in vitro, human epidermal rnelanocytes and melanoma cell
## Abstract In contrast to sunlight‐induced squamous cell carcinoma the etiology of cutaneous malignant melanoma (CMM) is not well understood. In particular, the role that sunlight exposure and DNA damage play in the initiation of this deadly form of cancer is an open question. Early UV carcinogene