Alternative procedure for the synthesis
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Martı́n A. Iglesias-Arteaga; Elena Castellanos; Eusebio Juaristi
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Article
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2003
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Elsevier Science
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English
⚖ 177 KB
The title heterocycle is prepared in enantiomerically pure form and in 46-50% overall yield from (S)-asparagine, a readily available starting material. The synthetic route described in this report represents a major improvement over the original procedure (Tetrahedron: Asymmetry 1991, 3, 723), that