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The phosphorothioite method 2. Use of S-(t-butyl) β-cyanoethyl phosphorothioites of deoxyribonucleoside for the synthesis of oligodeoxyribonucleosides on polymer supports

✍ Scribed by Mitsuo Fujii; Hajime Nagai; Mitsuo Sekine; Tsujiaki Hata


Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
246 KB
Volume
28
Category
Article
ISSN
0040-4039

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✦ Synopsis


S-(t-Butyl) S-cyanoethyl 3'-phosphorothioites of appropriately protected deoxyribonucleosides were prepared by the use of (t-butylthio)-B-cyanoethoxychlorophosphine as a new phosphitylatinq reagent. These


📜 SIMILAR VOLUMES


Alternative procedure for the synthesis
✍ Martı́n A. Iglesias-Arteaga; Elena Castellanos; Eusebio Juaristi 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 177 KB

The title heterocycle is prepared in enantiomerically pure form and in 46-50% overall yield from (S)-asparagine, a readily available starting material. The synthetic route described in this report represents a major improvement over the original procedure (Tetrahedron: Asymmetry 1991, 3, 723), that