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The phosphatidylinositol-3 kinase/Akt pathway mediates geranylgeranylacetone-induced neuroprotection against cerebral infarction in rats

✍ Scribed by Eiji Abe; Minoru Fujiki; Yasuyuki Nagai; Kong Shiqi; Takeshi Kubo; Keisuke Ishii; Tatsuya Abe; Hidenori Kobayashi

Book ID
113504883
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
548 KB
Volume
1330
Category
Article
ISSN
0006-8993

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## Abstract Excitotoxicity and cell death induced by glutamate are involved in many neurodegenerative disorders. We have previously demonstrated that excitotoxicity induced by millimolar concentrations of glutamate in hippocampal slices involves apoptotic features and glutamate‐induced glutamate re