The pharmacokinetics of the enantiomers of flurbiprofen in patients with rheumatoid arthritis.
โ Scribed by MA Young; L Aarons; S Toon
- Book ID
- 117945115
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 566 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0306-5251
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Flurbiprofen is a chiral 2-arylpropionate used clinically as a racemate. Previously a significant pharmacokinetic interaction between the enantiomers of flurbiprofen has been reported in both rats and humans. The possible mechanism for this interaction was believed to involve competitive protein bin
## Abstract ## Objective There is evidence supporting a therapeutic range for methotrexate polyglutamate (MTXGlu) concentrations in the treatment of rheumatoid arthritis (RA). Knowledge of the pharmacokinetics of MTXGlu~1โ5~ is required for optimal timing of blood sampling. The aim of this study w