𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The pharmacokinetics of exaprolol and propranolol in rats with interrupted enterohepatic circulation

✍ Scribed by O. Motheová; Š. Bezek; M. Ďurišová; V. Faberová; M. Zemánek; K. Mišánikova; T. Trnovec

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
509 KB
Volume
7
Category
Article
ISSN
0142-2782

No coin nor oath required. For personal study only.

✦ Synopsis

The pharmacokinetics of two beta adrenoceptor blocking drugs, exaprolol and propranolol, in rats with interrupted enterohepatic circulation was studied. The tritium-labelled drugs were given intravenously to four groups of rats: control, bile-duct cannulated, bile-duct ligated, and pretreated with neomycin. Plasma levels and excretion were observed up to 96 h after administration. The pharmacokinetic parameters show an enhanced plasma elimination of both drugs at interrupted enterohepatic circulation compared to the control group. Significant changes were observed in the excretion pattern with bile-duct cannulated and bile-duct ligated rats, while the total radioactivity excreted in urine and faeces does not differ between control and neomycin pretreated rats.

📜 SIMILAR VOLUMES

Biliary excretion and enterohepatic circ
Biliary excretion and enterohepatic circulation of two beta-adrenergic blocking drugs, exaprolol and propranolol in rats
✍ O. Tomčíková; Š. Bezek; M. Ďurišová; V. Faberová; M. Zemánek; T. Trnovec 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 428 KB 👁 2 views

Plasma levels and excretion of two beta-adrenoceptor blocking drugs 3H-exaprolol and 3H-propranolol were observed up to 96h after a single i.v. administration to rats. Terminal half-lives of 26.8k9.1 h and 51.3\_+7.5h were found for exaprolol and propranolol, respectively. The recovery of 3H radioac

Pharmacokinetics of intravenous luxabend
Pharmacokinetics of intravenous luxabendazole in rabbits: influence of the enterohepatic circulation
✍ Lucía Álvarez-Bujidos; Ana I. Ortiz; Irene T. Molina-Martínez; Carlos Cubría; Da 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 163 KB 👁 1 views

Luxabendazole (LBZ) is a new benzimidazole carbamate chemotherapeutic agent, which has proved to be very effective against adult and immature stages of the major gastrointestinal nematodes, trematodes and cestodes. While information on the efficacy of LBZ in several animal species is available, ther

Physiologic cholestasis II: Serum bile a
Physiologic cholestasis II: Serum bile acid levels reflect the development of the enterohepatic circulation in rats
✍ William M. Belknap; William F. Balistreri; Frederick J. Suchy; Philip C. Miller 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 497 KB

We have shown that serum bile acid concentrations are elevated in human infants reflecting physiologic immaturity of the enterohepatic circulation. To define further the ontogeny of bile acid metabolism in mammals, we examined maturational changes in the serum concentration of total cholate conjugat

Influence of endotoxin on the stereosele
Influence of endotoxin on the stereoselective pharmacokinetics of oxprenolol, propranolol, and verapamil in the rat
✍ Martine E. Laethem; Prof. Dr. Frans M. Belpaire; Pascal Wijnant; Marie-Thérèse R 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 613 KB

The influence of endotoxin-induced inflammation on the enantioselective phannacokinetics of propranolol, oxprenolol, and verapamil, which bind to a,-acid glycoprotein, was studied in the rat. The racemic mixtures were given orally. In the control animals, for propranolol and oxprenolol, the plasma c