The pharmacokinetics of alcohol in human breath, venous and arterial blood after oral ingestion

Investigation of 5-FU disposition after

Investigation of 5-FU disposition after oral administration of capecitabine, a triple-prodrug of 5-FU, using a physiologically based pharmacokinetic model in a human cancer xenograft model: comparison of the simulated 5-FU exposures in the tumour tissue between human and xenograft model

✍ Yuko Tsukamoto; Yukio Kato; Masako Ura; Ikuo Horii; Tohru Ishikawa; Hideo Ishits 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 274 KB 👁 2 views

## Abstract The nonlinear pharmacokinetics of capecitabine, a triple prodrug of 5‐FU preferentially activated in tumour tissues, was investigated in human cancer xenograft models. A physiologically based pharmacokinetic (PBPK) model integrating the activation process of capecitabine to 5‐FU and 5‐F