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The pharmacokinetics and pharmacodynamics of warfarin in combination with ambrisentan in healthy volunteers

✍ Scribed by Walker, Gennyne (author);Mandagere, Arun (author);Dufton, Christopher (author);Venitz, Jürgen (author)

Book ID
108642281
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
665 KB
Volume
67
Category
Article
ISSN
0306-5251

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✍ Rebecca Spence; Arun Mandagere; Brooke Harrison; Christopher Dufton; Ramesh Boin 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 225 KB

Ambrisentan is a nonsulfonamide, ET(A)-selective endothelin receptor antagonist (ERA) approved for the treatment of pulmonary arterial hypertension (PAH), and tadalafil is a phosphodiesterase type 5 (PDE-5) inhibitor under investigation for treatment of PAH. Due to the potential combination use, the