In a cross-sectional study of the pharmacokinetics and pharmacodynamics of peroral and intravenous bumetanide (0.5 mg, single dose), total and renal clearance of the diuretic was si~ni6cantly lower in elderly persons than in young adults, resulting in higher bumetanide plasma levels in the aged. Non
The pharmacokinetics and pharmacodynamics of bumetanide in normal subjects
โ Scribed by Laurence A. Marcantonio; William H. R. Auld; Graham G. Skellern; Christine A. Howes; W. Ronald Murdoch; Rameshwar Purohit
- Book ID
- 112474458
- Publisher
- Springer
- Year
- 1982
- Tongue
- English
- Weight
- 681 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1573-8744
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๐ SIMILAR VOLUMES
The effects of temporary water deprivation for 48 h on the pharmacokinetics and pharmacodynamics of bumetanide were examined after intravenous (i.v.) administration of bumetanide, 8mg kg-' to control and water deprived rats (n=7). The values of AUC, t,,, and MRT increased 79.0, 417, and 633 per cent
Bumetanide is a loop diuretic that is used for the treatment of edema and hypertension. The rapidly developing syndrome of extracellular fluid overload in some malnourished children has been successfully treated with furosemide, another loop diuretic, and digoxin; however, similar studies with bumet