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The Pharmacokinetics and Bioavailability of Prochlorperazine Delivered as a Thermally Generated Aerosol in a Single Breath to Volunteers

โœ Scribed by Avram, MJ; Spyker, DA; Henthorn, TK; Cassella, JV


Book ID
109845519
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
273 KB
Volume
85
Category
Article
ISSN
0009-9236

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Assessment of ifosfamide pharmacokinetic
โœ Rashmi Chugh; Thomas Wagner; Kent A. Griffith; Jeremy M.G. Taylor; Dafydd G. Tho ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 190 KB

## Abstract ## BACKGROUND. Ifosfamide is a chemotherapeutic agent that requires cytochrome P450 3A (CYP3A) for bioactivation and metabolism. To the authors' knowledge, the correlation between dose, pharmacokinetics, CYP3A, and toxicity has not been fully evaluated. A randomized Phase II trial was