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The pharmacokinetic–pharmacodynamic approach to a rational dosage regimen for antibiotics

✍ Scribed by P.L Toutain; J.R.E del Castillo; A Bousquet-Mélou


Book ID
117209218
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
691 KB
Volume
73
Category
Article
ISSN
0034-5288

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Pharmacokinetic/pharmacodynamic modeling
✍ Katsube, Takayuki (author);Yano, Yoshitaka (author);Wajima, Toshihiro (author);Y 📂 Article 📅 2010 🏛 John Wiley and Sons Inc. 🌐 English ⚖ 170 KB

The aim of this study was to obtain information on effective dosage regimens of doripenem by a modeling and simulation approach based on pharmacokinetic (PK)/pharmacodynamic (PD) theory. The PK/PD model we have already developed was modified to explain in vitro bactericidal kinetics of doripenem for