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The pharmaco-genetics of congenital cardiac defects in retinoic acid receptor deficient mouse embryos

โœ Scribed by Henry M. Sucov; Vicky LaMorte; Jiangming Luo; Vincent Giguere; Ronald M. Evans


Book ID
118584702
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
150 KB
Volume
27
Category
Article
ISSN
1558-3597

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We previously reported that retinoic acid shows a dose-dependent differential induction of various cardiac outflow anomalies: transposition of the great arteries is induced mainly by a high dose (70 mg/kg) and dextroposition of the aorta by a low dose (40-60 mg/kg; Yasui et al., 1995). We subsequent