The Persistent Radical Effect: From Mechanistic Curiosity to Synthetic Tool

✍ Scribed by Kathy-Sarah Focsaneanu; Juan C. Scaiano

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: German
• Weight: 112 KB
• Volume: 89
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200690227

✦ Synopsis

Abstract

The Fischer–Ingold persistent radical effect (PRE) provides a simple conceptual framework to rationalize reactivities in systems involving two radicals with very different self‐reaction rate constants; in a limiting, but rather common case, one of these radicals is persistent at room temperature. In these cases, the cross‐coupling product is strongly favored. This contribution summarizes some of the work carried out at the University of Ottawa, where the PRE plays a key role in determining product distributions. Much of this work was inspired by the seminal contributions of Hanns Fischer.