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The peroxisome proliferator-activated receptor-α (PPAR-α) agonist, AVE8134, attenuates the progression of heart failure and increases survival in rats

✍ Scribed by Linz, Wolfgang; Wohlfart, Paulus; Baader, Manuel; Breitschopf, Kristin; Falk, Eugen; Schäfer, Hans-Ludwig; Gerl, Martin; Kramer, Werner; Rütten, Hartmut

Book ID: 109832508
Publisher: Nature Publishing Group
Year: 2009
Tongue: Chinese
Weight: 714 KB
Volume: 30
Category: Article
ISSN: 1671-4083
DOI: 10.1038/aps.2009.58

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## Abstract Peroxisome proliferator‐activated receptor alpha (PPARα) is a member of the nuclear hormone receptor superfamily that can be activated by natural fatty acids and various xenobiotics, including clofibrate. This transcription factor primarily regulates genes involved in lipid metabolism a