The permeability of the frog liver to certain lipoid-insoluble substances

✍ Scribed by Haywood, Charlotte ;Höber, Rudolf

• Publisher: Wiley (John Wiley & Sons)
• Year: 1937
• Tongue: English
• Weight: 839 KB
• Volume: 10
• Category: Article
• ISSN: 0095-9898
• DOI: 10.1002/jcp.1030100305

✦ Synopsis

The present study investigates the secretion of the isolated frog liver with respect to certain lipoid-insoluble substances which have been added in small amounts to its supply of perfusion fluid. Our purpose in so doing has been twofold: first, to secure information as to the limiting size of lipoid-insoluble molecule which can gain access to the bile, and secondly, to ascertain whether the passage of lipoid-insoluble molecules through the liver into its secretion is attended by any alteration in their concentration.

Although it has long been recognized that those substances which a r e readily soluble in the lipoids of the cell membrane are able to enter the cells and tissues with ease (discussed by Jacobs, '24) , relatively recent investigations have made it increasingly evident that lipoid-insoluble non-electrolytes are also able to gain an entrance if their molecules are sufficiently small (Ruhland and Hoffmann, '25 ; Collander and Barlund,