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The perinatal and postnatal toxicity of d-methylphenidate and d,l-methylphenidate in rats

โœ Scribed by Steve K Teo; David I Stirling; Steve D Thomas; Alan M Hoberman; Mildred S Christian; Vikram D Khetani


Book ID
114273846
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
171 KB
Volume
16
Category
Article
ISSN
0890-6238

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## Abstract **BACKGROUND:** D,Lโ€__threo__โ€Methylphenidate (D,Lโ€MPH) is marketed currently for attention deficit hyperactivity disorder in children. Dโ€__threo__โ€methylphenidate (dexmethylphenidate; Dโ€MPH) is a refined formulation of D,Lโ€methylphenidate containing only the active enantiomer and was r

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## Abstract **BACKGROUND:** The oral administration of d,lโ€methylphenidate (MPH) was designed to encompass the major part of postnatal development in the rat and to evaluate potential chronic effects. **METHODS:** Wistar Hannover rats were crossโ€fostered on postpartum day 0 (day of birth) and were