The perinatal and postnatal toxicity of d-methylphenidate and d,l-methylphenidate in rats
โ Scribed by Steve K Teo; David I Stirling; Steve D Thomas; Alan M Hoberman; Mildred S Christian; Vikram D Khetani
- Book ID
- 114273846
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 171 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0890-6238
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## Abstract **BACKGROUND:** D,Lโ__threo__โMethylphenidate (D,LโMPH) is marketed currently for attention deficit hyperactivity disorder in children. Dโ__threo__โmethylphenidate (dexmethylphenidate; DโMPH) is a refined formulation of D,Lโmethylphenidate containing only the active enantiomer and was r
## Abstract **BACKGROUND:** The oral administration of d,lโmethylphenidate (MPH) was designed to encompass the major part of postnatal development in the rat and to evaluate potential chronic effects. **METHODS:** Wistar Hannover rats were crossโfostered on postpartum day 0 (day of birth) and were