The peptide antibiotic subtilin acts by formation of voltage-dependent multi-state pores in bacterial and artificial membranes

Voltage-dependent depolarization of bact

Voltage-dependent depolarization of bacterial membranes and artificial lipid bilayers by the peptide antibiotic nisin

✍ H. -G. Sahl; M. Kordel; R. Benz 📂 Article 📅 1987 🏛 Springer 🌐 English ⚖ 507 KB

The peptide antibiotic nisin is shown to disrupt valinomycin-induced potassium diffusion potentials imposed on intact cells of Staphylococcus cohnii 22. Membrane depolarization occurred rapidly at high diffusion potentials while at low potentials nisin-induced depolarization was slower suggesting th