𝔖 Bobbio Scriptorium
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The pentose shunt in wild-type and glucose-6-phosphate dehydrogenase deficientDrosophila melanogaster

✍ Scribed by Geer, B. W. ;Bowman, J. T. ;Simmons, J. R.

Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
852 KB
Volume
187
Category
Article
ISSN
0022-104X

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✦ Synopsis

Abstract

Four‐day old Drosophila melanogaster homozygous or hemizygous for the glucose‐6‐phosphate dehydrogenase mutant allele, Zw^−^, possess slightly less than 10% as much glucose‐6‐phosphate dehydrogenase activity in whole‐fly homogenates as their wild‐type, Zw^+^, counterparts. The reduction of glucose‐6‐phosphate dehydrogenase activity in Zw^−^ adults had no effect upon 6‐phosphogluconate dehydrogenase, phosphofructokinase, or malic enzyme activities. However, activities of the non‐oxidative pentose shunt enzymes were significantly greater in Zw^−^ adults than in Zw^+^ adults. Radiotracer procedures indicate that the oxidative phase of the pentose shunt is blocked in Zw^−^ adults. Zw^−^ larvae grow less well on a defined minimal amino acid diet lacking fatty acids and whole nucleic acid than do Zw^+^ larvae, indicating that Zw^−^ individuals have a lower biosynthetic capacity than Zw^+^ individuals.

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