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The pentachlorophenol metabolite tetrachloro-p-hydroquinone induces the formation of 8-hydroxy-2-deoxyguanosine in liver DNA of male B6C3F1 mice

✍ Scribed by Dahlhaus, Michael; Almstadt, Elke; Appel, Klaus E.


Book ID
123292598
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
763 KB
Volume
74
Category
Article
ISSN
0378-4274

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The alkaline single cell gel electrophoresis (SCGE) or "comet" assay under alkaline conditions was used to measure DNA damage in the liver cells of B6C3F1 male mice exposed to 2,4-dimethylaniline and 2,4,6-trimethylaniline. Cells embedded in agarose were lysed, subjected briefly to an electric field