✦ LIBER ✦
The penetration of ciprofloxacin into bronchial mucosa, lung parenchyma, and pleural tissue after intravenous administration
✍ Scribed by M. Dan; K. Torossian; D. Weissberg; R. Kitzes
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 231 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0031-6970
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✦ Synopsis
We have studied the concentrations of ciprofloxacin in serum, bronchial mucosa, lung parenchyma, and pleural tissue after a single intravenous dose of 200 mg in 20 patients subjected to lung surgery. The concentrations of ciprofloxacin in the tissues exceeded that in the serum by 3-fold to 7-fold: serum 0.6 micrograms.ml-1, bronchial mucosa 1.9 micrograms.g-1, lung parenchyma 3.4 micrograms.g-, and pleural tissue 1.7 micrograms.g-1. The achievable concentrations of ciprofloxacin in the tissues of the lower respiratory tract are above the MICs for most lung pathogens.