✦ LIBER ✦

The pathophysiology of lymphedema

✍ Scribed by Peter S. Mortimer

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 106 KB
Volume: 83
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19981215)83:12b+<2798::aid-cncr28>3.0.co;2-e

No coin nor oath required. For personal study only.

✦ Synopsis

All edemas result from an imbalance between capillary filtration and tissue (lymph) drainage. This basic approach was adopted to investigate mechanisms for chronic arm edema following breast carcinoma treatment.

METHODS.

A review of causes of lymphedema is presented plus the traditional pathophysiology of breast carcinoma related lymphedema (postmastectomy edema; PME). A summary of recent research that explored capillary filtration as a surrogate for lymph flow in the steady state is presented.

RESULTS.

A reduced interstitial protein concentration (relative to plasma) argues against lymphatic obstruction. Evidence exists that total arm blood flow (in some patients) and vascular bed size are increased in PME.

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