The pathobiology of focal lesion development in aging human articular cartilage and molecular matrix changes characteristic of osteoarthritis

Role of apoptotic and matrix-degrading g

Role of apoptotic and matrix-degrading genes in articular cartilage and meniscus of mature and aged rabbits during development of osteoarthritis

✍ Andrew T. Pennock; Catherine M. Robertson; Bryan C. Emmerson; Frederick L. Harwo 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 408 KB 👁 2 views

## Abstract ## Objective To determine expression patterns of apoptotic and matrix‐degrading genes during aging and development of osteoarthritis (OA), using a rabbit model of induced OA. ## Methods Six mature and 6 aged rabbits underwent anterior cruciate ligament transection and were killed 4 a