✦ LIBER ✦
The partial synthesis of some naturally occurring glycosphingolipids with special reference to 0-β-D-galactosyl-(1→4)-0-β-D-galactosyl-(1→1)-ceramide
✍ Scribed by J.B. Hay; G.M. Gray
- Publisher
- Elsevier Science
- Year
- 1969
- Tongue
- English
- Weight
- 505 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0009-3084
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✦ Synopsis
A procedure is described for the preparation of some naturally occurring glycosphingolipids by partial synthesis from natural ceramide (N-acylsphingosine). The ceramide was obtained in quantitative yield from sphingomyelin by the action of phospholipase C. It was converted to 3-0-benzoyl-ceramide which was then condensed with the chosen acetobromosugar in the presence of mercuric cyanide.
Details of the preparations of 0-fl-D-glucosyl-(l ~ 1) ceramide, 0-fl-D-lactosyl-(I -+ l)ceramide and 0-fl-D-galactosyl-(l ~ 4)-0-fl-D-galactosyl(l-~ 1)-ceramide are given.