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The paraoxonase-1 pathway is not a major bioactivation pathway of clopidogrel in vitro

✍ Scribed by V Ancrenaz; J Desmeules; R James; P Fontana; J-L Reny; P Dayer; Y Daali

Book ID
115290918
Publisher
Nature Publishing Group
Year
2012
Tongue
English
Weight
1015 KB
Volume
166
Category
Article
ISSN
0007-1188

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Aromatic hydroxylation is a major metabo
Aromatic hydroxylation is a major metabolic pathway of the mycotoxin zearalenone in vitro
✍ Erika Pfeiffer; Andreas Hildebrand; Georg Damm; Andreas Rapp; Benedikt Cramer; H πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 869 KB

## Abstract Zearalenone (ZEN) is a common mycotoxin, for which only reductive metabolites have been identified so far. We now report that ZEN is extensively monohydroxylated by microsomes from human liver __in vitro__. Two of the major oxidative metabolites arise through aromatic hydroxylation and