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The parallel synthesis of peptide based phosphine ligands

โœ Scribed by Scott R. Gilbertson; Xifang Wang

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
600 KB
Volume
55
Category
Article
ISSN
0040-4020

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โœฆ Synopsis

Chemistry is reported that allows for the synthesis and screening of phosphine ligands by standard combinatorial technology. To demonstrate the method, libraries of phosphine containing peptides were synthesized. Rhodium was complexed to the phosphine ligands while they were attached to the synthesis support. Each member of the library was screened for its ability to catalyze the asymmetric hydrogenation of enamides.

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