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The Palladium-Catalyzed Trifluoromethylation of Aryl Chlorides

โœ Scribed by Cho, E. J.; Senecal, T. D.; Kinzel, T.; Zhang, Y.; Watson, D. A.; Buchwald, S. L.

Book ID
121510211
Publisher
American Association for the Advancement of Science
Year
2010
Tongue
English
Weight
315 KB
Volume
328
Category
Article
ISSN
0036-8075

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Palladium-catalyzed amination of aryl ch
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Pd(PCy3)CI 2 (Cy = cyclohexyi) catalyzed the rcactioa of aryl cldmides and ~,,octdary amln~ in the pre~ncยข of NaOtBu to give the ~g aryl amines in good to excellent yields. In of dte reactions, an excess amouat of aryl chloride (atyl chloride/amine = 2) improved the yields.

First palladium-catalyzed aminations of
First palladium-catalyzed aminations of aryl chlorides
โœ Matthias Beller; Thomas H. Riermeier; Claus-Peter Reisinger; Wolfgang A. Herrman ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 136 KB

## The palladium-catalyzed coupling reaction of aryl chlorides with various amines has been studied for the first time. Crucial for the success of this C-N bond forming reaction is the use of potassium tertbutoxide as base. Turn over numbers up to 900 and yields up to 80 % have been obtained.