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The PACOVAR-trial: A phase I/II study of pazopanib (GW786034) and cyclophosphamide in patients with platinum-resistant recurrent, pre-treated ovarian cancer

✍ Scribed by Michael Eichbaum; Christine Mayer; Regina Eickhoff; Esther Bischofs; Gerhard Gebauer; Tanja Fehm; Florian Lenz; Hans-Christian Fricke; Erich Solomayer; Nikos Fersis; Marcus Schmidt; Markus Wallwiener; Andreas Schneeweiss; Christof Sohn


Book ID
115010384
Publisher
BioMed Central
Year
2011
Tongue
English
Weight
191 KB
Volume
11
Category
Article
ISSN
1471-2407

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## Abstract ## BACKGROUND: Aberrant DNA methylation is a hallmark of cancer, and DNA methyltransferase inhibitors have demonstrated clinical efficacy in hematologic malignancies. On the basis of preclinical studies indicating that hypomethylating agents can reverse platinum resistance in ovarian c