The development and survival of sympathetic neurons is critically dependent on the related neurotrophic factors nerve growth factor (NGF) and neurotrophin-3 (NT3), the actions of which must be executed appropriately despite spatial and temporal overlaps in their activities. The tyrosine receptor kin
β¦ LIBER β¦
The p75 neurotrophin receptor influences NT-3 responsiveness of sympathetic neurons in vivo
β Scribed by Brennan, Christine; Rivas-Plata, Kimberly; Landis, Story C.
- Book ID
- 109476707
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 390 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1097-6256
- DOI
- 10.1038/11158
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## Abstract Neurotrophinβ3 (NTβ3) can negatively modulate trkA and associated phenotype in intact sensory neurons, while positively regulating trkC and associated phenotype. How NTβ3 effects this response is not clear. Whether NTβ3 exerts a differential influence on levels of activated ERK1/2 signa