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The p53/IGF-1 receptor axis in the regulation of programmed cell death

✍ Scribed by Manfred Neuberg; Leonard Buckbinder; Bernd Seizinger; Nikolai Kley

Publisher
Springer
Year
1997
Tongue
English
Weight
330 KB
Volume
7
Category
Article
ISSN
0969-711X

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## Abstract The insulin‐like growth factor‐I receptor (IGF‐IR) is a ubiquitous multifunctional tyrosine kinase that has an important role in normal cell growth and development. However, abnormal stimulation of IGF‐IR signaling has been implicated in the development of different types of tumors. The