𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The p53 tumor suppressor participates in multiple cell cycle checkpoints

✍ Scribed by Luciana E. Giono; James J. Manfredi

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
216 KB
Volume
209
Category
Article
ISSN
0021-9541

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The process of cell division is highly ordered and regulated. Checkpoints exist to delay progression into the next cell cycle phase only when the previous step is fully completed. The ultimate goal is to guarantee that the two daughter cells inherit a complete and faithful copy of the genome. Checkpoints can become activated due to DNA damage, exogenous stress signals, defects during the replication of DNA, or failure of chromosomes to attach to the mitotic spindle. Abrogation of cell cycle checkpoints can result in death for a unicellular organism or uncontrolled proliferation and tumorigenesis in metazoans (Nyberg et al., 2002). The tumor suppressor p53 plays a critical role in each of these cell cycle checkpoints and is reviewed here. J. Cell. Physiol. 209: 13–20, 2006. Β© 2006 Wiley‐Liss, Inc.

πŸ“œ SIMILAR VOLUMES

The p53 tumor suppressor protein regulat
The p53 tumor suppressor protein regulates hematopoietic stem cell fate
✍ Takashi Asai; Yan Liu; Narae Bae; Stephen D. Nimer πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 179 KB

## Abstract The p53 tumor suppressor protein is a key transcription factor that regulates several signaling pathways involved in the cell's response to stress. Through stress‐induced activation, p53 accumulates and triggers the expression of target genes that protect the genetic integrity of all ce

Inhibition of cell-cycle effectors of pr
Inhibition of cell-cycle effectors of proliferation in bladder tumor epithelial cells by the p75NTR tumor suppressor
✍ Fatima Khwaja; Daniel Djakiew πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 209 KB

## Abstract The neurotrophin (NTR) receptor (p75^NTR^) is a cell‐surface glycoprotein that binds to the neurotrophin family of growth factors, of which the prototypic member is nerve growth factor (NGF). This receptor was previously shown to retard cell‐cycle progression by inducing accumulation of

Molecular alchemy of the tumor suppresso
Molecular alchemy of the tumor suppressor protein p53: Metals and cell growth control
✍ Catherine MΓ©plan; Pierre Hainaut πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 769 KB

The p53 protein is an ubiquitous multifunction, zinc-binding transcription factor that is activated in response to multiple forms of stress and that controls proliferation, survival, DNA repair, and differentiation of cells exposed to potentially genotoxic DNA-damage. Loss of p53 function by mutatio