✦ LIBER ✦

The p38 pathway inhibitor SB202190 activates MEK/MAPK to stimulate the growth of leukemia cells

✍ Scribed by Megumi Hirosawa; Masako Nakahara; Risa Otosaka; Akemi Imoto; Toshio Okazaki; Shinichiro Takahashi

Book ID: 104040859
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 536 KB
Volume: 33
Category: Article
ISSN: 0145-2126
DOI: 10.1016/j.leukres.2008.09.028

No coin nor oath required. For personal study only.

✦ Synopsis

In this study, the biological effects of signal transduction inhibitors on leukemia cells were examined. We found that the p38 inhibitor SB202190 enhanced the growth of THP-1 and MV4-11 cells. To determine the pathway affected by SB202190, we examined the 50% effective dose (ED 50 ) values for THP-1 cell growth in combination with several inhibitors. In the presence of SB202190, the ED 50 values for the farnesyltransferase inhibitor FPT inhibitor II and MEK inhibitor U0126 were significantly decreased. Western blot analysis revealed that SB202190 increased the phosphorylation of C-Raf and extracellular regulated kinase (ERK), suggesting that Ras-Raf-MEK-mitogen-activated protein kinase (MAPK) pathway activation is involved in the leukemia cell growth induced by SB202190.

📜 SIMILAR VOLUMES

Growth factor-dependent activation of th

Growth factor-dependent activation of the MAPK pathway in human pancreatic cancer: MEK/ERK and p38 MAP kinase interaction in uPA synthesis

✍ Kyung Hee Lee; Myung Soo Hyun; Jae-Ryong Kim 📂 Article 📅 2003 🏛 Springer 🌐 English ⚖ 278 KB

Activation of p38 MAPK pathway contribut

Activation of p38 MAPK pathway contributes to the melanogenic property of apigenin in B16 cells

✍ Yan Ye; Hui Wang; Jian-Hong Chu; Gui-Xin Chou; Zhi-Ling Yu 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 313 KB

Differential regulation of mast cell cyt

Differential regulation of mast cell cytokines by both dexamethasone and the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580

✍ R. D. KORANTENG; E. J. SWINDLE; B. J. DAVIS; R. J. DEARMAN; I. KIMBER; B. F. FLA 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 126 KB

Signaling pathways leading to the induct

Signaling pathways leading to the induction of ornithine decarboxylase: Opposite effects of p44/42 mitogen-activated protein kinase (MAPK) and p38 MAPK inhibitors

✍ Flavio Flamigni; Annalisa Facchini; Emanuele Giordano; Benedetta Tantini; Claudi 📂 Article 📅 2001 🏛 Elsevier Science 🌐 English ⚖ 354 KB

Nox4 mediates the expression of plasmino

Nox4 mediates the expression of plasminogen activator inhibitor-1 via p38 MAPK pathway in cultured human endothelial cells

✍ Amandine Jaulmes; Patricia Sansilvestri-Morel; Gaëlle Rolland-Valognes; Fabienne 📂 Article 📅 2009 🏛 Elsevier Science 🌐 English ⚖ 447 KB

The MEK/MAPK pathway is involved in the

The MEK/MAPK pathway is involved in the resistance of breast cancer cells to the EGFR tyrosine kinase inhibitor gefitinib

✍ Nicola Normanno; Antonella De Luca; Monica R. Maiello; Manuela Campiglio; Maria 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 287 KB 👁 1 views

## Abstract We investigated the role of the MEK/MAPK pathway in the sensitivity/resistance of breast carcinoma cells to the EGFR tyrosine kinase inhibitor gefitinib (IRESSA). We assessed the effects of gefitinib on the growth of three breast cancer cell lines that showed high (SK‐Br‐3; IC~50~ 4 µM)