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The p21RAS Farnesyltransferase alpha Subunit in TGF-beta and Activin Signaling

✍ Scribed by Wang, T.; Danielson, P. D.; Li, B.-y.; Shah, P. C.; Kim, S. D.; Donahoe, P. K.


Book ID
121155824
Publisher
American Association for the Advancement of Science
Year
1996
Tongue
English
Weight
761 KB
Volume
271
Category
Article
ISSN
0036-8075

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Examination of the effect of the farnesylprotein transferase (FPTase) inhibitor UCF1-C/manumycin on NIH3T3 cells transfected with a normal N-ras gene and expressing high levels of the corresponding p21-ras protein showed that 10 m UCF1-C immediately and reversibly inhibited growth in these cells, wi