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The oxidatively induced DNA lesions 8,5′-cyclo-2′-deoxyadenosine and 8-hydroxy-2′-deoxyadenosine are strongly resistant to acid-induced hydrolysis of the glycosidic bond

✍ Scribed by Jacob A. Theruvathu; Pawel Jaruga; Miral Dizdaroglu; P.J. Brooks


Book ID
113776066
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
638 KB
Volume
128
Category
Article
ISSN
0047-6374

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Divergent effects of oxidatively induced
✍ Jessy Abraham; Philip J. Brooks 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 341 KB 👁 1 views

## Abstract DNA is exposed to endogenous and environmental factors that can form stable lesions. If not repaired, these lesions can lead to transcription/replication blocking or mutagenic bypass. Our previous work has focused on 8,5′‐cyclopurine 2′‐deoxyribonucleosides, a unique class of oxidativel