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The oxidation of the highly tumorigenic benz[a]anthracene 3,4-dihydrodiol by rat liver dihydrodiol dehydrogenase

✍ Scribed by Jochen Klein; Karin Post; Helmut Thomas; Walter Wörner; Frans Setiabudi; Heinz Frank; Franz Oesch; Karl L. Platt


Book ID
113137355
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
854 KB
Volume
76
Category
Article
ISSN
0009-2797

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The racemic anti-dihydrodiol epoxide of 7-methylbenz[a]anthracene preferentially induced mutations at G.C base pairs in the pS189 shuttle vector. Mutations were not randomly distributed throughout the supF target gene, but were concentrated at five hotspots. The hotspots for this agent did not corre