The oxidation of isomeric amino and acetamidobiphenyls by rat hepatic microsomal preparations
β Scribed by Nejla Bayraktar; M. Kajbaf; S. D. Jatoe; J. W. Gorrod
- Book ID
- 104710691
- Publisher
- Springer-Verlag
- Year
- 1987
- Tongue
- English
- Weight
- 195 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0340-5761
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The effect of endogenous glycogen on lipid peroxidation was examined in hepatic microsomes from rats. Microsomes were prepared to retain endogenous hepatic glycogen (P,') or to minimize it (P,-). The indices of lipid peroxidation examined included the rate of NADPH-dependent formation of malondialde
Glucuronidation of carboxylic acids, primarily catalyzed by hepatic UDPglucuronosyltransferases, is an important phase II metabolic pathway functioning in detoxification. Acyl glucuronides of 2-aryl propionates, however, can form covalently bound protein adducts, which may generate hypersensitive re