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The osteoclast Ca2+ receptor is highly sensitive to activation by transition metal cations

✍ Scribed by Vijai S. Shankar; Christopher M.R. Bax; A.S.M.Towhidul Alam; Bridget E. Bax; Christopher L.-H. Huang; Mone Zaidi

Book ID
115765289
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
376 KB
Volume
187
Category
Article
ISSN
0006-291X

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Earlier studies have demonstrated that a high (mM) extracellular CaL+ concentration triggers intracellular [Ca"] signals with a consequent inhibition of bone resorptive activity. We now report that micromolar concentrations of the divalent cation, Ni'+, elicited rapid and concentration-dependent ele