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The osteocalcin gene: a model for multiple parameters of skeletal-specific transcriptional control

✍ Scribed by Gary S. Stein; Jane B. Lian; André J. van Wijnen; Janet L. Stein

Book ID
110241458
Publisher
Springer
Year
1997
Tongue
English
Weight
169 KB
Volume
24
Category
Article
ISSN
0301-4851

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We have analyzed the linkage of protein phosphorylation to the remodeling of chromatin structure that accompanies transcriptional activity of the rat osteocalcin (OC) gene in bone-derived cells. Short incubations with okadaic acid, an inhibitor of protein phosphatases 1 and 2A, induced marked change