The orthogonal character of stationary phases for gas chromatography

✍ Scribed by Salwa K. Poole; Colin F. Poole

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 267 KB
• Volume: 31
• Category: Article
• ISSN: 1615-9306
• DOI: 10.1002/jssc.200700546

✦ Synopsis

Abstract

A database of system constants for 32 open‐tubular columns at 100°C is used to identify stationary phases for obtaining a wide selectivity space in comprehensive GC. Three parameters based on the Euclidean distance (D‐parameter) or vectors (d‐parameter and cosθ) in hyperspace are used to establish the chemical similarity and retention correlation as an inverse scale of selectivity differences. It is shown that the poly(methyloctylsiloxane) stationary phase is the best candidate for a low‐selectivity stationary phase and affords a wider selectivity space when combined with a selective polar stationary phase than poly(dimethylsiloxanes). The most suitable polar stationary phases are poly(ethylene glycols) or bis(cyanopropylsiloxane‐co‐silarylenes and to a lesser extent poly(methyltrifluoropropylsiloxanes). No systems are truly orthogonal but angles between individual stationary phase vectors of about 75° are possible by choosing the correct combination of stationary phases.