Blood was drawn from 74 children, 3-16 years old, at diagnosis of Type 1 (insulin-dependent) diabetes and before the first insulin injection. Insulin autoantibodies were detected with a polyethylen-glycol-method in 27/74 (36.4%) and with an immuno-electrophoretic method in 6/74 (8.1%). Islet cell cy
The ontogeny of islet cell antibodies (I.C.A.) in insulin dependent diabetic children and their immediate family
β Scribed by Pilcher, C.C.; Elliott, R.B.
- Book ID
- 122738593
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 83 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0896-8411
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The role of complement in the pathogenesis of diabetes was studied in 31 Type 1 (insulin-dependent) diabetic children by assaying serum islet cell surface antibody, C3, C4 and serum complement-dependent antibody-mediated cytotoxicity. Nine of 21 islet cell surface antibody-positive children were wit
Islet cell antibodies and glutamic acid decarboxylase II (GAD II) antibodies have been discussed in the autoimmune pathogenesis of insulin-dependent diabetes mellitus (IDDM). Hence, immunosuppressants, intravenous immunoglobulins, and plasmapheresis have been used in an effort to modulate autoimmune